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Soluble Globular Human Albumin Serum HSA Protein Unglycosylated For Vaccine Formulation

HY100M1

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Description

Soluble Globular Human Albumin Serum HSA Protein Unglycosylated For Vaccine Formulation?
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Quick detail
# # CAS No.: 70024-90-7
# Other Names: rHSA
# EINECS No.: 274-272-6
# Brand Name: Oryzogen
# Model Number: HY100M1
# Source: Rice Grain (Oryza Sativa)
# Endotoxin: Less than 0.25EU/mg
# Storage and Handling: Stored at temperatures 2-8℃ for 24 months


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Physiological and Biochemical Properties of rHSA and pHSA

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Char. | pHSA | rHSA |
Amino Acids Sequence | Same | Same |
N-terminus | DAHKSEV | DAHKSEV |
C-terminus | KLVAASQAALGL | KLVAASQAALGL |
Glycosylation | No | No |
Molecular Mass(MALDI) | 66.554KD | 66.550KD |
PI | 4.8 | 4.8 |
Drug Binding | Similar | Similar |
Thermal Stability | M/P 65℃ | M/P 65℃ |
Lipid Conjugation | Identical | Identical |
Crystal Structure | Identical | Identical |
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Description

Vaccine development is an important way for human to fight against infectious diseases. rHSA can be used in vaccine research and development of the culture. Our rHSA are derived from plants, without any potential risk of animal origin, radically avoiding the exogenous virus pollution.



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Advantages

1.?Healthgen recombinant human serum albumin is free of animal origin, which effectively avoid any potential risk of animal bacteria, prions, virus and contagious protein disease.

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2. Healthgen recombinant human serum albumin (rHSA) has excellent batch consistency. Using self-pollination rice as the bioreactor to express the rHSA, with the world& acute;s advanced facility and top production proceeding to extract and purify the rHSA, Healthgen can ensure the excellent consistency of rHSA from different batches.

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3.?The rice endosperm specific expression platform is easy to be large-scale. The rice endosperm has the protein body, which can keeps proteins stability and bioactivity.

At present, the production capacity is almost 1000 kg / year.

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4.?Recombinant human serum albumin (rHSA) has good efficacy, such as rHSA has the same second and tertiary structure, physiological and biochemical properties with HAS from plasma. In addition, compared with HSA from plasma, rHSA has a lower immune source stimulation, and plays a better role in accelerating cell growth and metabolism, because rHSA is animal component free, which can avoid the prions or virus contaminants.

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Supplemental Description

Human serum albumin has been widely used as plasma expansion reagent. Because of its non-enzymatic activity and no immunogenicity, etc. HSA can also be used as excipient and stabilizer in a variety of pharmaceutical preparations and serum-free cell culture medium component. In addition, HSA is also used as a drug carrier due to its antioxidant properties, thereby conferring drugs better physicochemical properties. At present, most HSA products in the market are directly derived and refined from human plasma.

On the one hand, due to the potential existence of various infectious disease pathogens in the human blood, especially AIDS, hepatitis B and other viruses. Thereby, these virus from human plasma will be brought with HSA to the final products. rHSA produced by gene recombinant technology can effectlively avoid the risks of virus pollution and infection. What’s more, the supply of human blood is limited. Therefore, it’s very urgent to search blood substitutes. The establishment and development of recombinant DNA technology provide an important method for the acquisition of biological materials. In recent years, many researchers have been hotly committed to the recombinant human serum albumin research.

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