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Dried Artemether And Lumefantrine Oral Suspension Medicine For Antimalaria

Artemether 180mg+Lumefantrine 180mg

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Description

Dried oral suspension- artemether +Lumefantrine suspenions for antimalaria 180mg+1080mg/60ml

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Product Information

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Artemether + Lumefantrine Oral Suspension is the World Health Organization’s #1 choice treatment used to treat malaria, a potentially deadly disease caused by parasites. ? The base of artemether is artemisinin, a natural antimalarial derived from the Chinese medicinal plant Artemisia annua. Lumefantrine is an aryl amino alcohol comparable to quinine, mefloquine, and halofantrine. ? When these two active substances are combined, they can be used in the treatment of uncomplicated infections with Plasmodium falciparum, including strains from multi-drug resistant areas. ? This combination of the substances kills the malaria-causing parasite by damaging its membrane. Because this product is used to kill the organisms that cause malaria, it should not be used for malaria prevention. ? This high quality product is manufactured with GMP standards.
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Artemether+Lumefantrin Oral Suspension Anti malarial 180MG+1080MG/60ML

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The combination of artemether and lumefantrine is used to treat certain kinds of malaria infections. Artemether and lumefantrine should not be used to prevent malaria. Artemether and lumefantrine is in a class of medications called antimalarials. It works by killing the organisms that cause malaria.

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COMPOSITION:

Each 180/1080 package contains Artemether 180mg and Lumefantrine 1080mg.

Each 360/2160 package contains Artemether 360mg and Lumefantrine 2160mg.

Excipients include Sodium Citrate, Carmellose Sodium, Sucrose, Sodium Benzoate, Colloidal anhydrous silica, Aspartame, flavour.

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PHARMACOLOGICAL ACTION:

Both components of tablets have their own action site in the malarial parasite. The presence of the endoperioxide bridge in Artemether (generating singlet oxygen and free radicals: those are very cytotoxic to the plasmodia) appears to be essential for antimalarial activity. Morphological changes of the parasitic membranes induced by Artemether have been described, being the result of free-radical action.

Lumefantrine interferes more in the polymerization processes.

Other in vitro tests suggest that both cause a marked diminution of nucleic acid synthesis. Inhibition of protein synthesis as the basic mechanism of action is suggested in studies which showed morphological changes in ribosomes as well as in the endoplasmic reticulum. Although Artemether acts essentially as a blood schizonticide, tablets did clear gametocytes in comparative clinical trials.

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INDICATIONS:

Tablet is indicated for the treatment of malaria in children, caused by all forms of Plasmodium including severe malaria caused by multiple drug resistant strains of P. Falciparum.

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CONTRA-INDICATIONS:

Sensitivity to cimetidine or related agents.
Should not be administered to pregnant or lactating patients.

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DOSAGE AND DIRECTIONS FOR USE:

Shake the bottle to loosen powder inside. Add water to the mark point and shake well. Adjust the volume up to the mark if necessary. The suspension must be used within one week after preparation. Shake well before use.


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SIDE EFFECTS AND SPECIAL PRECAUTIONS:
With Artemether virtually no side effects have been seen. Laboratory abnormalities such as a slight rise in transaminases and a decrease in reticulocyte count are rare and transient. A lowering of sinus frequency without causing ECG changes has been noticed. At high doses transient abdominal pain, tinnitus and diarrhea have been described but a causal relationship is unclear.
Some antimalarials as halofantrine and quinine can influence the ECG pattern. Attention should be made to patients previously treated with those antimalarials. A reasonable period should be taken in account before to start a. treatment with lumefantrine combinations. For those patients physicians will be prescribed Artemismin derivatives in mono therapy in cause of severe paludism. Sometimes it could be possible that the following common side effect occur; rash, check this with you doctor. Other common side effects may occur as trouble of sleeping, nausea, vomiting, diarrhea, coughing. They need medical attention when persisting.

STORAGE INSTRUCTIONS:

Store below 25°C in a closed bottle. Once the suspension has been made up, it is stable for a minimum of one week. Longer conservation is not recommended. Protect from light.

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